As the hospital is preoccupied with a nuclear disaster drill, a study participant's pregnancy further divides Masters and Johnson. Meanwhile, Margaret learns the truth about her husband, and Haas finds his days at the hospital may be numbered.
Now that Jane is working as Masters' secretary, Johnson looks to advance her own career by finishing her college degree, starting with Dr. DePaul's anatomy class. While Margaret is devastated when Langham loses interest in her, she still ends their affair graciously. Masters turns to a college employee named Lester Linden to help film their sessions. Though Lester adapts their equipment to get a detailed look at female sexual arousal, once he's asked to film Jane, it's clear that he has no idea what he agreed to.
While Nate and Francine Bombeck's new baby is genetically male, he's born with both male and female sex organs. Though Masters encourages them to take some time to think it over and then he can authorize a surgery to see that the baby can be raised as a male, Nate doesn't want the child to grow up under the cloud of sexual ambiguity and insists that the male organs be removed.
While mining their shared history over a family dinner, Masters bristles at Frank's insinuations about his and Estabrooks' demons. Virginia continues to impersonate a patient's case history in order to glean advice from a psychiatrist. Betty and Masters attempt to help Lester remedy his impotence by hiring a prostitute, rattling him even further.
The shockwaves surrounding the events of Masters and Johnson's first press conference begin to reverberate around their universe as the book nears its release date. Bill takes on a powerful, high profile fertility patient with the help of a new doctor in the practice, while Virginia and Libby come to terms with Bill's role in Gini's life.