Masters and Johnson continue their research in the brothel but skewed data confirms that Masters must get the study back into the hospital. At the hospital, Johnson is surprised to learn that a distinguished new doctor on the OB/GYN floor is a woman who has no interest in female solidarity. Meanwhile, Libby struggles to conceive and Dr. Ethan Haas gets the case of a lifetime - a woman pregnant with quadruplets.
With the study back in the hospital, Masters and Johnson recruit new participants on campus. But Johnson is shocked when her ex-husband George, who's crashing on her couch, wants to sign up. Masters' mother comes to visit, but her new take on life stirs up painful memories of his childhood. And Libby's attempt at playing matchmaker with Virginia and Ethan doesn't go as smoothly as she'd hoped.
Virginia's parents arrive unannounced. Meanwhile, Libby and Bill Masters discover Johnny has been bullied and look to fix it in their own way. Plus, Virginia finds unexpected excitement in the scent study while Bill, looking to overcome his embarrassing departure from the university, takes on a promising fertility patient that could land him and Johnson back in favour.